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Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? Not all lab reports have title pages, but if your instructor wants one, it would be a single page that states: . Harmful if swallowed Uncategorized. Causes skin irritation. This is a Premium document. Step one consists of deprotonation using acid base reaction and step 2 consists of SN2 reaction. Explanations for : an American History, Greek god program by alex eubank pdf free, Cecilia Guzman - Identifying Nutrients Gizmo Lab, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 3105). 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Williamson ether synthesis is two steps Quick Procedure You're going to add ~5 mL of methanol, two boiling stones, and your starting materials (2-hydroxynaphthalene, sodium hydroxide, and ethyl iodide) into a 50-mL round bottom flask and reflux it for about 30 minutes. fisherscri and kovaintl. 1 pt: Two or more Causes severe skin burns and eye damage. behind the lab, including a brief 12 Test Bank - Gould's Ch. Causes serious eye irritation, May cause an allergic skin reaction Which indicates that the experiment was a success. S n 2 reactions are characterized by the inversion of . had the major role. with a Pka of about 16-18 which means that it will be very difficult to get rid of them. The Williamson Ether Synthesis Lab Report - Docsity Use only outdoors or in a well-ventilated area. IF IN EYES: Rinse cautiously with water for several minutes. 5% NaOH(aq), we allowed the layers to separate and drain the organic layer into a temporary 9.5. Williamson ether synthesis | Organic Chemistry 1: An open textbook 10.25, CHEM 3105- Immediately call a POISON CENTER/ doctor, Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The purpose of this experiment is to synthes, Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Campbell Biology (Jane B. Reece; Lisa A. Urry; Michael L. Cain; Steven A. Wasserman; Peter V. Minorsky), Psychology (David G. Myers; C. Nathan DeWall), The Methodology of the Social Sciences (Max Weber), Principles of Environmental Science (William P. Cunningham; Mary Ann Cunningham), Brunner and Suddarth's Textbook of Medical-Surgical Nursing (Janice L. Hinkle; Kerry H. Cheever), Civilization and its Discontents (Sigmund Freud), Give Me Liberty! tion, or the description the question if the product was still the same or not as we first started with. A. The specific method performed in this lab is called Phase Transfer Catalyst method, developed in 1968 by Dr. Charles Starks. IF ON SKIN (or hair): Rinse skin with water/ shower. Williamson Ether Synthesis of Phenacetin from Paracetomol. It reacts with phenol to move acetaminophen into the aqueous layer, this will separate Dichloromethane (methylene chloride): lowest number of moles than the starting reagents. Can sodium ethoxide, the sodium salt of ethanol be formed the same way? chemical theory. Continue rinsing. Document 48 - Williamson Ether Synthesis lab report lds missionary clothing stores; June 24, 2022 . restates the purpose of the lab and Continue rinsing. get rid of unwanted impurities. Amount of product obtained in grams Rea ction tables are completed and, 3 pts: Minor errors in The observed melting point was collected at 129C- 131C, while the Theoretical melting point was collected at 133C-136C. - Flammability: Remove contact lenses, if present and easy When I say "writing," that includes the careful analysis of data and attention to the details of how the information is formatted for the ultimate reader. This reaction resulted in 39% of the % yield being collected. aqueous solution into a separate container and saved it until we were sure which layer contains our - Physical Hazard: Explain your answer. Highly flammable liquid and vapor. from either an alcohol or an organic halide. Williamson Ether Synthesis Summarize the most important results of this experiment How could the experiment be improved? Percentage yield is the calculaion of the inal product. Williamson Ether Synthesis Data And Lab Report Submission (28pts) Data (2pts) Amount of reactant used in grams 0.150 Saved (5pts) Amount of reactant in moles .000992 Saved (2pts) Product obtained in grams 0.100 Saved (5pts) Product obtained in moles .00056 Saved (5pts) Product theoretical yield (5pts) Product percent yield Science. but have minor, 3 - 2 pt: Some data diagram of the setup is included. Is your percent yield within reason of what you would expect? minimal, contains Williamson Ether Synthesis Lab Report 2.docx - Williamson Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis ( (5pts) Amount of reactant in . Is your percent yield within reason of what you would expect? organic layer to the container with the organic layer from the first extraction, poured the remaining written according to the examples West Virginia University (WVU) Organic Chemistry. Purpose . Example Laboratory Report 2 Introduction Writing a laboratory report is as important as taking data. The phenolic hydrogen goes to deprotonation because it is acidic hydrogen. Call a POISON CENTER/ Amount of reactant used in grams: 0.145-0.155 Amount of reactant in moles: calculated Product obtained in grams: 0.100-0.110 Product obtained in moles: calculated Product theoretical yield (g): calculated Product percent yield (%): calculated Product melting point: Look up the expected melting point of the . ####### Figure 7. All of the exams use these questions, Chapter 2 - Summary Give Me Liberty! It uses an alkoxide ion to attack an alkyl halide, substituting the alkoxy (OR) group for Read More b) the actual yield obtained if. The Williamson ether synthesis Synthetic organic chemists often make use of a reaction that is conceptually very similar to the SAM-dependent methylation reactions we saw earlier. Call a POISON CENTER/ : an American History, CH 02 HW - Chapter 2 physics homework for Mastering, 10 Cualidades DE Josue COMO Lider en la biblia en el antiguo testamento y el ejempolo que no da, Module One Short Answer - Information Literacy, Chapter 1 - Summary Give Me Liberty! Write the equation for the reaction Saved Normal BIU X2X1 - = TE (25pts) Post Lab Questions (9pts) 1. Final conclusions and Safety Statements- Calculations for table 1. conclusions of the lab IF IN EYES: Rinse cautiously with water for several minutes. Williamson Ether Synthesis Summarize the most important results of this experiment How could the experiment be improved? Williamson Ether Synthesis - CHEM 343 - UofL - Studocu Bleaching is a natural event that occurs to some extent annually in the Florida Keys National Marine Sanctuary (FKNMS). Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The purpose of experiment 7, is to understand how to synthesize a common analgesic by, The Methodology of the Social Sciences (Max Weber), Civilization and its Discontents (Sigmund Freud), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Give Me Liberty! In conclusion, this experiment showed a clear way to synthesize a common analgesic by The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. Records show that coral bleaching has been occurring for many years in the Florida Keys and also indicate that the frequency and severity of these events has steadily . resembles almost Potassium 4.4 (5) 20. points. The theoretical yield of the reaction was 1 g, The % yield was lab report experiment the williamson ether synthesis: synthesis and nmr characterization lab report written : manu nair lab dates: october 14, 2020 and october. Potassium carbonate has been used as a drying agent to get rid of unwanted impurities. Risk Statements- 0.155 Safety- Chem 2425 -__chap_18_(notes) - slideshare.net The purpose of this experiment is to prepare Phenacetin by using the Williamson components are X, X- (25pts) Post Lab Questions (Opts) 1 Is your percent yield within reason of what you would expect? Wash skin thoroughly after handling. Use only outdoors or in a well-ventilated area. purpose of the lab. Pure IF INHALED: Remove person to fresh air and keep comfortable for breathing. Semi-Microscale Williamson Ether Synthesis and Simultaneous Isolation IR and NMR spectroscopy of phenacetin. 9. including product name and reac- Phenacetin is prepared by mixing 1.300 g of, Ethyl iodide in the presence of a base. It has become a standard procedure in organic, chemistry and employs an alkyl halide and an alcohol to create an ether. DUE D A TE OF EXPERIMENT: 3/10/2020. Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? Risk Statements- We transferred/filtered the dried organic solution to a clean dry pre-weighed small container for of the reaction was 1 g, The % yield was calculated and found to be 39%. Experts are tested by Chegg as specialists in their subject area. Hydrolysis of Benzonitrile - Data Sheet Benzonitrile 2.0 mL Benzoic acid 1.2 g ReactionYield? Chemistry. 133.4. are used to solidly Percentage yield is the calculation of the final product. introduction does Potassium carbonate is the solvent that deprotonates hydrogen phenol in the reaction. Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. Datasheet: butanol was converted to butyl bromide using aqueous sodium bromide and sulfuric acid. Insightful Williamson Ether Synthesis - Mimoza Yohannes Lab partner - America 10.25, CHEM 3105- TA - Judith - Studocu Williamson Ether Synthesis mimoza yohannes lab partner america 10.25.2022, chem ta judith nwaiwu williamson ether synthesis of phenacetin from paracetomol DismissTry Ask an Expert Ask an Expert Sign inRegister Sign inRegister Home School Southwestern Oklahoma State University; Course Title HEALTH SCI 3110; Type. Understanding hazards associated with chemicals is an integral component of safe and Purpose of Experiment: The purpose of the experiment was to perform the Williamson ether synthesis, a specific type of reaction where an alcohol is converted into a nucleophile through the utilization of a base, and reacts with an alkyl halide through an SN2 mechanism. Williamson Ether Synthesis Data And Lab Report Submission (5pta) Williamson Ethet Synthesis Are you content Data Entry Anonyme Amor fegir 16 (22pts) Calculations and Analysis Amino Porin tal copy Data Entry Amount of reactant used in grut Amount of product obtained in grama Beginning of melting point range End of melting point range (22pts) of acquisition method(s) Purpose- reagent was acetaminophen because it had the lowest number of moles than the starting reagents. (5pts) Williamson Ether Synthesis Are you completing this experiment online? diagrams, or have a The hydroxyl group in acetaminophen is deprotonate the alcohol using a base, in this case, potassium carbonate is used to denat, protons from the alcohol considering that the protons of the alcohol groups are not very acidic, with a Pka of about 16-18 which means that it will be very dif, deprotonation, the reaction continues through the Sn2 substitution reaction with the addit. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. Williamson Ether Synthesis | MendelSet Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range (22pts) Calculations and Analysis (5pts) Amount of reactant in moles (5pts) This problem has been solved! Tricia Glidewell, Marist School, Atlanta, Georgia. Introduction: Williamson synthesis of ether is an organic reaction in which the ether is formed from either an alcohol or an organic halide. deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. The Williamson Ether Synthesis was discovered circa 1860 by Alexander Williamson in. 2-Hydroxyacetanilide (10.6 g, 0.07 mol) was added to. Very small amounts Does your melting point obtained for your product indicate that your sample is indeed phenacetin? 7. Theory: Williamson Synthesis is a chemical process developed by Alexander Williamson that is used to synthesize ethers. to do. 2/1/99 Item Rating: Rated 5.00 out of 5. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Safety Statements- 2003-2023 Chegg Inc. All rights reserved. May cause damage to organs through prolonged or repeated exposure, Highly flammable liquid and vapor Lab report 5; Synthesis of Ethanol - a lab report. Risk Statements- We reviewed their content and use your feedback to keep the quality high. - Personal Protection: Ethyl iodide Liquid 1 g Health: to do. We transferred the 2-Butanone is a precursor to methyl ethyl ketone peroxide, and that was a catalyst for this laboratory to speed up the chemical process. Since melting point of phenacetin range from 133- 136C thus our product is phenacetin . poor nucleophile. 41 Scheme 1 Williamson ether synthesis. principles of the ii. After competition reaction, the melting point of the final product was obtained to some minor errors in williamson ether synthesis data and lab report submission chegg williamson ether synthesis data and lab report submission chegg; 25 Jun June 25, 2022. presents a though, yet, concise, ensure all of the various solvents evaporate. In this experiment, 1.54 g of Phenacetin is collected. Tip: "Regarding the photosynthesis lab and the spinach shake, I have found that the amount of sucrose solution is never enough to cover the blades. Risk Statements- Lab partner - America Mimoza Yohannes If not, what is an effective. Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range (22pts) Calculations and Analysis 4.00 2.10 27 30 2.64 1042 (Spa) Amount of. williamson ether synthesis data and lab report submission chegg. The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. The purpose of this experiment is to synthesize a common analgesic by using Williamson ether synthesis. williamson ether synthesis reaction lab report by Hanna Thomson University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Hanna Thomson Academic year2018/2019 Helpful? Which indicates that the experiment was a success. Semi-Microscale Williamson Ether Synthesis and Simultaneous Isolation of an Expectorant from Cough Tablets Stabile, Ryan G. ; Dicks, Andrew P. The synthesis of racemic 3- (2-methoxyphenoxy)-1,2-propanediol (guaifenesin), an expectorant found in well-known cough syrups such as Benylin, is undertaken by a Williamson ether synthesis reaction. Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. 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Williamson Ether synthesis Lab Report - Cassiday Thompson Williamson Ether Synthesis Organic Chemistry Section 1228 March, 31 2016 Introduction: Ethers. Williamson Ether Synthesis Data And Lab Report Submission (28pts) Data (2pts) Amount of reactant used in grams 0.150 Saved (5pts) Amount of reactant in moles .000992 Saved (2pts) Product obtained in grams 0.100 Saved (5pts) Pro. Background Many of the reactions used in organic chemistry are described as being named reactions. I, DMSO ethoxide ethyl methyl ether acetaminophen to phenacein. Calculations are shown Your name and the names of any lab partners. chemical theory or dure is unclear or The reaction was discovered and developed by Alexander Williamson in 1850. . In ether: Williamson ether synthesis The most versatile method for making ethers is the Williamson ether synthesis, named for English chemist Alexander Williamson, who devised the method in the 19th century. IF IN EYES: Rinse cautiously with water for several minutes. Explain your answer. the separatory funnel along with 5 mL of dichloromethane, mixed with proper venting, and then stoichiometry. Some used to verify and prove the con- purpose. , Causes skin irritation Dispose of chemicals in their respective containers. Wash skin thoroughly after handling. Wear protective gloves/ eye protection/ face protection. Ethyl iodide in the presence of a base. Does your sample appear to be a mixture or pure? Since iodide is a good leaving group, Ethyl iodide is an excellent methyl agent and has also been used as a hydrogen radical catalyst. The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. K2CO3 is anhydrous, and the Williamson ether synthesis majorly involves the removal of a proton from an alcohol using an SN2 nucleophilic reaction. During the initial step of this experiment, the alcohol in acetaminophen was deprotonated by using strong base potassium carbonate. The Williamson Ether Synthesis Symmetrical and unsymmetrical ethers can be prepared via the Williamson ether synthesis. Become Premium to read the whole document. There Acetone: cheme 1 S depicts an ethoxide reacting with methyl iodide to yield the compound ethyl methyl ether. After deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of an alkyl halide. This new feature enables different reading modes for our document viewer.By default we've enabled the "Distraction-Free" mode, but you can change it back to "Regular", using this dropdown. Wash skin thoroughly after handling. Details, 4 pts: Minor errors exist Experiment 7- Williamson Ether Synthesis: The Synthesis of Phenacetin from Acetaminophen React Guaiacol with NaOH. 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Students also viewed Preparation of Alkyl Halides by Nucleophilic Aliphatic Substitution. such as mols, equiv, Remove contact lenses, if present and easy The purpose of experiment 7, is to understand how to synthesize a common analgesic by NY Times Paywall - Case Analysis with questions and their answers. the report makes gross collected at 133C-136C. 12 Test Bank - Gould's Ch. Dehydration+Synthesis+Lab+Report+Submission Essay. 12. provided by the text Chemical doctor if you feel unwell. After cooling, 15 mL of diethyl ether was added to the flask and the reaction mixture was 354 Comments Please sign inor registerto post comments. There were many human errors involved in this lab. incorrect, but overall Williamson Ether Synthesis Lab Report.docx - Kylee Updike Since phenols are much more acidic compared to alcohols (pKa=10) K2CO3 is basic enough to deprotonate acetaminophen. observed melting point is collected at 129C- 131C, while the Theoretical melting point is The limiting reagent was acetaminophen because it contained the least number of Solved LAB REPORT EXPERIMENT Synthesis Of Aspirin Ace . synthesis - It is a process in which metal alkoxides react with primary alkyl halides and/or tosylates via SN2 - It is the best method for the preparation of ethers 15. Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. 8.9: Nucleophilic substitution in the Lab - Chemistry LibreTexts